Antidepressant and Psychedelic Drug Interactions

antidepressant ayahuasca drug interaction ibogaine ketamine mdma psilocybin selective serotonin reuptake inhibitor Nov 06, 2021

Antidepressant and Psychedelic Interactions

The most common situations and clinical scenarios I consult about have to do with persons taking antidepressants that are interested in psychedelic therapies or have tried them while taking antidepressants with lackluster results. 

It’s truly a conundrum for serotonergic psychedelics as to how persons can best approach this work when the toughest part of it all may be weaning existing medications and getting the psychedelics to be potent and therapeutic. I offer all levels of support for this process beginning with this FREE resource.

What the Antidepressant and Psychedelic Interaction and Taper Planning Guide Guide Contains

Antidepressant and Psychedelic Drug Interaction Potential

The first section explores the drug interaction potential between psychedelics such as MDMA, psilocybin, LSD, ayahuasca, and ketamine in combination with antidepressants such as SSRIs, SNRIs, bupropion, and mirtazapine. 

Antidepressant and Psychedelic Drug Interaction Chart

The second section summarizes drug interactions between antidepressants and psychedelics in an at a glance and evidence-based chart. This chart has been the most popular resource I've ever created!

Tapering Antidepressants Safely and Successfully 

The third section provides an overview of the challenges persons face when attempting to taper and stop antidepressants. It also details strategies to help persons succeed safely.

Antidepressant Taper Monitoring Tool

The final section gives the reader a taper planner and monitoring tool that allows users and providers to gauge readiness to taper, customize a plan based on responses to dose decreases, and track progress. 

 I know this area is one that can be both complicated and challenging for persons and their providers to navigate. People deserve the information contained in the guide and I want them to have it at their fingertips. This is why I created the Antidepressant and Psychedelic Drug Interaction and Tapering Guide. It will help bring clarity to complex topics as well as allow persons to make sound decisions when choosing to transition from their antidepressants to psychedelic therapies as well as do so in safe and effective ways. I also offer a range of services to support persons in tapering antidepressants including individual consultations and taper planning, a member program with flexible options for follow up consultations or email based support, and an educational course for persons or providers to learn more about how to safely and effectively taper antidepressants. 


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